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Age increases anxiety and reactivity of the fear/anxiety circuit in Lewis rats

✍ Scribed by Ksenia Z. Meyza; Pawel M. Boguszewski; Evgeni Nikolaev; Jolanta Zagrodzka

Book ID
116286490
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
441 KB
Volume
225
Category
Article
ISSN
0166-4328

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The effects of chlordiazepoxide (7.5 mg/kg) were assessed on the performance of young (3 months) and old (12 months) hooded Lister rats in the elevated plus-maze test of anxiety. In young animals chlordiazepoxide significantly increased the percentage of entries onto open arms and the percentage of