Age-dependent differences in the rat's conditioned defensive burying behavior: Effect of 5-HT1A compounds
✍ Scribed by Carolina López-Rubalcava; Alonso Fernández-Guasti; Ruth Urbá-Holmgren
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 856 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0012-1630
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✦ Synopsis
The ontogeny of conditioned defensive-burying behavior was studied in rats from 2 to 21 weeks of age. At early ages this parameter shows low values that gradually increase until the 1 Ith week, decreasing steadily thereafter. Reactivity, measured by the burying-behavior latency, appeared increased in 2-week-old rats, The effect of the serotonergiclA compounds: 8-OH-DPAT (0.25 and 0.5 mg/kg), ipsapirone, buspirone, and indorenate (at 2.5 and 5.0 mg/kg) was studied at 3,7, 11, and 21 weeks of age. All compounds produced a dosedependent decrease in burying behavior in rats of 7 and I 1 weeks, while at the Week 21, only 8-OH-DPAT and indorenate reduced it. At 3 weeks of age, burying-behavior latency was increased by all compounds, but burying behavior was not altered. Motor coordination was affected by buspirone at all ages and by 8-OH-DPAT at the Week 21. Data are discussed on the bases of the development of defensive behaviors.