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Age-dependent degradation of amyloid precursor protein in the post-mortem mouse brain cortex

✍ Scribed by A. Asaithambi; Shibani Mukherjee; Mahendra K. Thakur


Book ID
110246736
Publisher
Springer
Year
1999
Tongue
English
Weight
103 KB
Volume
26
Category
Article
ISSN
0301-4851

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## Abstract We have generated immortal neuronal cell lines from normal and trisomy 16 (Ts16) mice, a model for Down syndrome (DS). Ts16 lines overexpress DS‐related genes (__App__, amyloid precursor protein; __Sod1__, Cu/Zn superoxide dismutase) and show altered cholinergic function (reduced cholin