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Age-dependent changes in thymic macrophages and dendritic cells

✍ Scribed by Alberto Varas; Rosa Sacedón; Carmen Hernandez-López; Eva Jiménez; Javier García-Ceca; Javier Arias-Díaz; Agustín G. Zapata; Angeles Vicente

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
136 KB
Volume
62
Category
Article
ISSN
1059-910X

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✦ Synopsis

Aging is characterized by the decline and deregulation of several physiological systems, especially the immune system. The involution of the thymus gland has been identified as one of the key events that precedes the age-related decline in immune function. Whereas the decrease in thymocyte numbers and in the thymic output during thymus atrophy has been analyzed by various authors, very little information is available about the age-associated modifications in thymic macrophages and dendritic cells. Here we present evidence that these thymic stromal cell components are only slightly affected by age.

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