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Age-dependent changes in the nervous and endocrine control of the thymus

✍ Scribed by Jonas Hannestad; Diego F. Monjil; Belén Díaz-Esnal; Juan Cobo; José A. Vega

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
284 KB
Volume
63
Category
Article
ISSN
1059-910X

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✦ Synopsis

Abstract

The immune system, especially the thymus, undergoes age‐related modifications leading to structural and functional changes in the lymphoid organs and immunocompetent cells. Nevertheless, the consequences of thymic involution in the peripheral pool of T‐cells are still a matter of controversy. The control of the thymic function is very complex and involves intrathymic signals, the autonomic nervous system, and the endocrine system. Both thymocytes and thymic stromal cells express receptors for a wide range of hormones, as well as for neurotransmitters and neuropeptides, thus affecting thymocytes maturation. This review summarizes the age‐dependent variations in the extrathymic components of the thymic microenvironment, i.e., vegetative nerves and hormones, and the possible effects of those changes in the immune function. Microsc. Res. Tech. 63:94–101, 2004. © 2004 Wiley‐Liss, Inc.

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