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Age-dependent and gender-specific changes in mouse tissue iron by strain

โœ Scribed by Paul Hahn; Ying Song; Gui-shuang Ying; Xining He; John Beard; Joshua L. Dunaief

Book ID
113615275
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
180 KB
Volume
44
Category
Article
ISSN
0531-5565

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## Abstract Huntington's disease (HD) is a neurodegenerative disorder characterized by the expansion of CAG repeats in exon 1 of the HD gene. To clarify the instability of expanded CAG repeats in HD patients, an HD model mouse has been generated by gene replacement with human exon 1 of the HD gene