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Age-dependent alteration of TGF-β signalling in osteoarthritis

✍ Scribed by Peter M. van der Kraan; Marie-José Goumans; Esmeralda Blaney Davidson; Peter ten Dijke


Publisher
Springer-Verlag
Year
2011
Tongue
English
Weight
294 KB
Volume
347
Category
Article
ISSN
0302-766X

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## Abstract Maintenance of the articular surface depends on the function of articular chondrocytes (ACs) which produce matrix and are constrained from undergoing the maturation program seen in growth plate chondrocytes. Only during pathologic conditions, such as in osteoarthritis, are maturational