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Age-associated changes in Ca2+-dependent processes: Relation to hippocampal synaptic plasticity

✍ Scribed by Thomas C. Foster; Christopher M. Norris

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 227 KB
Volume: 7
Category: Article
ISSN: 1050-9631
DOI: 10.1002/(sici)1098-1063(1997)7:6<602::aid-hipo3>3.0.co;2-g

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✦ Synopsis

Altered calcium (Ca 2؉ ) homeostasis is thought to play a key role in aging and neuropathology resulting in memory deficits. Several forms of hippocampal synaptic plasticity are dependent on Ca 2؉ , providing a potential link between altered Ca 2؉ homeostasis and memory deficits associated with aging. The current study reviews evidence for Ca 2؉ dysregulation during aging which could interact with Ca 2؉ -dependent synaptic plasticity. The authors suggest that changes in Ca 2؉ regulation could adjust the thresholds for synaptic modification, favoring processes for depression of synaptic strength during aging.

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