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Age-associated alterations in CD8α+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium

✍ Scribed by Gang Li; Megan J. Smithey; Brian D. Rudd; Janko Nikolich-Žugich

Book ID: 117954488
Publisher: John Wiley and Sons
Year: 2012
Tongue: English
Weight: 608 KB
Volume: 11
Category: Article
ISSN: 1474-9718
DOI: 10.1111/j.1474-9726.2012.00867.x

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## Abstract Insight into the mechanisms by which dendritic cells (DC) present exogenous antigen to T cells is of major importance in the design of vaccines. We examined the effectiveness of free antigen as well as antigen with lipopolysaccharide, emulsified in complete Freund's adjuvant, and antige