𝔖 Bobbio Scriptorium
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Agarose for a bioartificial pancreas

✍ Scribed by Iwata, Hiroo ;Takagi, Tatsuya ;Amemiya, Hiroshi ;Shimizu, Hiroshi ;Yamashita, Kazuya ;Kobayashi, Kazuo ;Akutsu, Tessuzo

Book ID
102873152
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
598 KB
Volume
26
Category
Article
ISSN
0021-9304

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✦ Synopsis

Islets were encapsulated into 5% concentration agarose microbeads. The effect of microencapsulation on islet allograft survivals was determined using a streptozotocin-induced diabetic (STZ) mouse and a nonobese diabetic (NOD) mouse as recipients. All five STZ BALB/c mice receiving microencapsulated islets (C57BL/6) maintained normoglycemia indefinitely. When NOD mice were used as recipients of the bioartificial pancreas, four of five grafts (islets from C3H/He) functioned for more than 80 d. Two of five NOD mice maintained normoglycemia until animals were sacrificed at 102 and 192 postoperative d. Microbeads made of commercially available agarose can effectively prolong alloislets functioning in the STZ-diabetic mouse and even in the NOD mouse (animal model of human type I diabetes) without the use of any immunosuppressive drug.

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