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African strains of hepatitis E virus that are distinct from Asian strains

✍ Scribed by Chatterjee, Ranee; Tsarev, Sergei; Pillot, Jacques; Coursaget, Pierre; Emerson, Suzanne U.; Purcell, Robert H.

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
52 KB
Volume
53
Category
Article
ISSN
0146-6615

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✦ Synopsis

Partial genomic sequences of four hepatitis E virus (HEV) strains from Africa (Morocco and Tunisia) and one from Central Asia (Tashkent, Uzbekistan) were obtained. The reverse transcriptase-polymerase chain reaction was used to amplify 5Ј and hypervariable regions of open reading frame 1 (ORF1) and a region overlapping all 3 ORFs. Sequence analysis of these regions revealed the African strains to be quite distinct from all known Asian strains but more similar to them than to the Mexican strain. Sequence analysis of the Tashkent strain revealed almost complete identity with another central Asian strain from Osh, Kirgizia. These results thus further confirm the geographical origin of HEV strain divergence.

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