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Aflatoxin exposure and risk of hepatocellular carcinoma in Taiwan

✍ Scribed by Li-Yu Wang; Maureen Hatch; Chien-Jen Chen; Bruce Levin; San-Lin You; Sheng-Nan Lu; Mei-Huei Wu; Wei-Pin Wu; Lian-Wen Wang; Qiao Wang; Guan-Tarn Huang; Pei-Ming Yang; Hsuan-Shu Lee; Regina M. Santella

Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
705 KB
Volume
67
Category
Article
ISSN
0020-7136

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✦ Synopsis

To investigate the carcinogenic effect of environmental aflatoxin exposure, 56 cases of hepatocellular carcinoma (HCC) diagnosed between I99 I and I995 were identified and individually matched by age, sex, residence and date of recruitment to 220 healthy controls from the same large cohort in Taiwan. Blood samples were analyzed for hepatitis B and C viral markers and for aflatoxin-albumin adducts; urine was tested for aflatoxin metabolites. We obtained information about sociodemographic characteristics, habitual alcohol drinking, cigarette smoking and diet in a structured interview. Hepatitis B virus surface antigen (HBsAg) carriers had a significantly increased risk for HCC. After adjustment for HBsAg serostatus, the matched odds ratio (OR,,,) was significantly elevated for subjects with high levels of urinary aflatoxin metabolites. When stratified into tertiles. a dose-response relationship with HCC was observed. The OR,,, for detectable aflatoxin-albumin adducts was not significant after adjustment for HBsAg serostatus. HBsAg-seropositive subjects with high aflatoxin exposure had a higher risk than subjects with high aflatoxin exposure only or HBsAg seropositivity only. In male HBsAg-seropositive subjects, adjusted ORs were 2.8 (95% confidence interval [CI] = 0.9-9. I)

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