✦ LIBER ✦

Affinity of recombinant antibody and antibody fragment binding to human thyroglobulin: potential applications in gene therapy

✍ Scribed by Jean-Claude Mani; Danièle Noel; Mariana Marin; Isabelle Navarro-Teulon; Martine Biard-Piechaczyk; Bernard Pau; Marc Piechaczyk

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 40 KB
Volume: 11
Category: Article
ISSN: 0952-3499
DOI: 10.1002/(sici)1099-1352(199812)11:1/6<117::aid-jmr404>3.0.co;2-o

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✦ Synopsis

Recombinant antibodies and antibody fragments are currently being produced. They can be used in vitro for the structural study of antigen-antibody interactions for instance, but their in vivo production may have applications for gene therapy of certain cancers and severe viral diseases and in developing new animal models of autoimmune disease. We report here these two types of applications using a recombinant antihuman thyroglobulin (hTg) antibody.