## Abstract The relative ability of the antiestrogen, tamoxifen, and its monohydroxy and desmethyl metabolites to displace tritiated estradiol from estrogen receptors isolated from human breast carcinoma was determined. 4‐Hydroxytamoxifen binds to the estrogen receptor with affinity equal to estrad
✦ LIBER ✦
Affinity of estradiol mustard for estrogen receptors and its enzymatic degradation in uterine and breast cancer cytosols
✍ Scribed by Guy Leclercq; Marie-Christine Deboel; Jean-Claude Heuson
- Publisher
- John Wiley and Sons
- Year
- 1976
- Tongue
- French
- Weight
- 539 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
The presence of specific estrogen receptors in a large proportion of human breast cancers has been demonstrated in several laboratories (McGuire et al., 1975), including ours (Leclercq et al., 1975). Specific receptors concentrate estrogens in the human cancer
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