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Affinity labeling of a nerve growth factor receptor component on rat pheochromocytoma (PC12) cells

โœ Scribed by Joan Massague; Stephen Buxser; Gary L. Johnson; Michael P. Czech

Book ID
115725836
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
659 KB
Volume
693
Category
Article
ISSN
0005-2736

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Treatment of PC12 cells with dexamethasone leads, in a period of days, to a 60% decrease in the binding of (125I)nerve growth factor. The decrease was maximal after 3 days of treatment with 1 microM dexamethasone, but some decrease was seen after 6 hr and at concentrations as low as 10 nM. The effec