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Affinity Capillary Electrophoresis: Insights into the Binding of SH3 Domains by Peptides Derived from an SH3-Binding Protein

✍ Scribed by Gomez, Frank A.; Chen, James K.; Tanaka, Akito; Schreiber, Stuart L.; Whitesides, George M.


Book ID
126822491
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
286 KB
Volume
59
Category
Article
ISSN
0022-3263

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Stability and peptide binding affinity o
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## Abstract We have determined the thermodynamic stability and peptide binding affinity of the carboxy‐terminal Src homology 3 (SH3) domain from the __Caenorhabditis elegans__ signal‐transduction protein Sem‐5. Despite its small size (62 residues) and lack of disulfide bonds, this domain is highly