## Abstract Primary afferent fibers are divided into three main subgroups: AΞ²β, AΞ΄β, and Cβfibers. Morphological studies have demonstrated that neonatal capsaicin treatment (NCT) depletes Cβfiber inputs in the spinal dorsal horn; the electrophysiological features of the NCTβinduced changes, however
Afferent C-fibres in rats after neonatal capsaicin treatment
β Scribed by E. Welk; E. Fleischer; U. Petsche; H. O. Handwerker
- Publisher
- Springer
- Year
- 1984
- Tongue
- English
- Weight
- 647 KB
- Volume
- 400
- Category
- Article
- ISSN
- 0031-6768
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While airway rapidly adapting receptors can mediate the cough reflex, much evidence suggests that bronchial C-fibre receptors are also involved in guinea-pigs and man. In man local and systemic C-fibre stimulants have a potent tussive action, which is blocked by low doses of local anaesthetics which
Other abbreviation used rn the text: CGRP, calcitonin gene-related peptide. This work was supported by grants from Direccion General de Investigacion Cientifica y Tecnica (PM91-0227, PB90-0994). The CGRP experiments were conducted with support from the Austrian Science Foundation (grant P9473-MED).
Newborn rats were treated with Capsaicin. Seven weeks later, calcitonin gene-related peptide, substance P, and serotonin were detected immunocytochemically in the dorsal horn of the spinal cord. Peptide immunostaining, presumably located in primary afferents, was reduced in intensity, whereas the pa