Aerosol direct fluorination: syntheses of the highly branched ketones, F-pinacolone and "F-provalone"

Trifluoromethanesulfonic acid, an altern

Trifluoromethanesulfonic acid, an alternative solvent medium for the direct electrophilic fluorination of DOPA: new syntheses of 6-[18F]fluoro-L-DOPA and 6-[18F]fluoro-D-DOPA

✍ Babak Behnam Azad; Raman Chirakal; Gary J. Schrobilgen 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 133 KB 👁 1 views

Previous work from this laboratory has shown that the direct fluorination of 3, 4-dihydroxy-phenyl-lalanine (l-DOPA) in anhydrous HF (aHF) or BF 3 /HF with F 2 is an efficient method for the synthesis of 6-fluoro-l-DOPA. Since then, 18 F-labeled 6-fluoro-l-DOPA ([ 18 F]6-fluoro-l-DOPA) has been used