𝔖 Bobbio Scriptorium
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Aegerolysins: Structure, function, and putative biological role

✍ Scribed by Sabina Berne; Ljerka Lah; Kristina Sepčić

Book ID
105356775
Publisher
Cold Spring Harbor Laboratory Press
Year
2009
Tongue
English
Weight
417 KB
Volume
18
Category
Article
ISSN
0961-8368

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✦ Synopsis

Abstract

Aegerolysins, discovered in fungi, bacteria and plants, are highly similar proteins with interesting biological properties. Certain aegerolysins possess antitumoral, antiproliferative, and antibacterial activities. Further possible medicinal applications include their use in the prevention of atherosclerosis, or as vaccines. Additional biotechnological value of fungal aegerolysins lies in their involvement in development, which could improve cultivation of commercially important edible mushrooms. Besides, new insights on microheterogeneity of raft‐like membrane domains could be gained by using aegerolysins as specific markers in cell and molecular biology. Although the exact function of aegerolysins in their producing organisms remains to be explained, they are biochemically well characterized all‐β structured proteins sharing the following common features: low isoelectric points, similar molecular weights (15–17 kDa), and stability in a wide pH range.

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