There are several reports on cardiac adverse reactions attributed to the antimigraine drug sumatriptan in the recent literature. In order to assess the frequency and the character of adverse reactions to sumatriptan, a postmarketing cohort study was performed one year after registration of the drug in The Netherlands.
With assistance of 86 % of the drug dispensing general practitioners in The Netherlands, 1727 patients who had received sumatriptan were traced in July, 1992. Via their general practitioners, a questionnaire about use of sumatriptan, adverse reactions and other medication was sent to the patients in December 1992. During the study period, seven patients were lost to follow-up. Of the 1720 remaining patients, 1202 (70 %) responded to the questionnaire, of whom 1187 had actually used sumatriptan.
The most frequently reported suspected adverse reactions were paraesthesiae (139patients, 95% CI 9.9%-13.5 %) and dizziness (96 patients, 95% CI 6.5 %-9.7 %). Chest pain after use of sumatriptan was reported by 94 patients (7.9 %, 95 % CI 6.4 %-9.4 %), and according to the close temporal relationship with the intake of sumatriptan and a positive rechallenge, a causal relationship was probable in most of those patients. The frequency of chest pain attributed to sumatriptan was higher in females (9.0 % vs 4.6 %; relative