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Adverse effects of dopamine potentiation by long-term treatment with selegiline

✍ Scribed by Susan Hollán; László Vécsei; Kálmán Magyar


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
53 KB
Volume
19
Category
Article
ISSN
0885-3185

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✦ Synopsis


Abstract

A patient with triosephosphate isomerase (TPI) deficiency exhibited worsening of abnormal involuntary movements of the dystonic type and developed psychiatric symptoms while on selegiline. When selegiline was stopped after 9 years of treatment, abnormal involuntary movements improved to pretreatment level and psychiatric behaviour returned to normal. Monoamine oxidase‐B platelet activity was low in this patient. © 2003 Movement Disorder Society


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## Abstract Changes in dopamine (DA) D~1~, D~2~, D~3~, and D~4~ receptors and serotonin 5‐HT~1A~ and 5‐HT~2A~ receptors in rat forebrain regions were autoradiographically quantified after continuous infusion of JL 13 [(5‐(4‐methylpiperazin‐1‐yl)‐8‐chloro‐pyrido[2,3‐__b__][1,5]benzoxazepine fumarate