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Adverse effects of chronic Akt activation in the heart: role of feedback inhibition of PI 3-kinase

✍ Scribed by Tomohisa Nagoshi; Takashi Matsui; Ling Li; Anthony Rosenzweig


Book ID
119588741
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
59 KB
Volume
9
Category
Article
ISSN
1532-8414

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## Abstract The PI3K‐AKT pathway can mediate diverse biological responses and is crucial for optimal immune responses and lymphocyte development. Deletion of PI3K subunits or AKT leads to blockage of T‐cell development at the TCR‐β checkpoint. Studies with over‐expression of constitutively activate