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Adverse effect of verapamil in myasthenia gravis

✍ Scribed by Dr. Michael Swash; David A. Ingram

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
248 KB
Volume
15
Category
Article
ISSN
0148-639X

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✦ Synopsis

Abstract

Verapamil, a class IV anti‐arrhythmic drug that blocks voltage‐dependent calcium channels in cardiac and smooth muscle, also has effects on presynaptic and postsynaptic voltage‐dependent calcium channels at the neuromuscular junction. In a postoperative patient with pre‐existent myasthenia gravis, oral verapamil caused a marked exacerbation in myasthenic weakness.

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