Background:
Surgery has been the mainstay of treatment for gastrointestinal (gi) lymphoma. the role of adjuvant chemotherapy to surgery has not been clearly elucidated.
Methods:
The review covered 100 patients who were diagnosed with primary gi lymphoma and treated from 1980 to 1993 at providence hospital (southfield, mi), and hartford and st. francis hospitals (hartford, ct) with a median follow-up of 5 years. forty-two patients were treated with surgery alone; 31 patients with surgery and adjuvant chemotherapy; 23 patients with primary chemotherapy, and 4 patients received no treatment.
Results:
The 5-year actuarial survival based on the above treatments calculated by life-table analysis were 57%, 76%, 58%, and 0%, respectively. this series showed that surgery with adjuvant chemotherapy significantly improved the 5-year actuarial survival of patients with primary gi lymphoma and that primary chemotherapy showed comparable survival to surgery alone. there was no difference in prognosis when comparing patients with different stage, grade, or location of disease in the gi tract.
Conclusions:
We recommend surgery when feasible with adjuvant chemotherapy as the mainstay of treatment for primary gi lymphoma. however, if a patient presents with comorbid factors, primary chemotherapy offers an effective alternative.