Advances in Virus Research

✍ Scribed by Kielian, Margaret; Maramorosch, Karl; Mettenleiter, Thomas

• Publisher: Academic Press,Elsevier
• Year: 2016
• Tongue: English
• Leaves: 179
• Series: Advances in Virus Research, Volume 94
• Edition: 1
• Category: Library

✦ Synopsis

Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews, providing a valuable overview of the current field of virology.

• Contain contributions from leading authorities
• Informs and updates on all the latest developments in the field of virology

✦ Table of Contents

Content: Front Cover
Advances in virus Research
Copyright
Contents
Contributors
Chapter One: Functional Genomic Strategies for Elucidating Human-Virus Interactions: Will CRISPR Knockout RNAi and Haploi ...
1. Introduction
2. Host-Virus Genetic Screens
3. RNAi Genetic Screening Technologies and Approaches
3.1. RNAi Pooled Screening
3.2. Arrayed RNAi Screening
3.3. RNAi Screening Problems and Some Solutions
4. Haploid Cell Genetic Screening Technology and Approach
5. CRISPR/Cas9 Genetic Screening Technologies and Approaches 6. Comparison of HRV-HF Screens: Arrayed MORR RNAi Versus Pooled CRISPR/Cas97. Future Directions
Acknowledgments
References
Chapter Two: Alphaherpesvirus Latency: A Dynamic State of Transcription and Reactivation
1. Introduction
2. A Working Definition of Latency
3. Model Systems to Study Alphaherpesvirus Latency
3.1. Natural Host Animal Models
3.2. NonNatural Host Models
3.3. Implant Tissue Models
3.4. In Vitro Models
3.4.1. Explant Models
3.4.2. Cell Culture Models of Latency
4. Establishment of Latency
4.1. Role of Cell Type in the Establishment of Latency 4.2. Initiation of Transcriptional Activation or Suppression4.3. Expression of lncRNAs and miRNAs
4.3.1. HSV-1
4.3.2. HSV-2
4.3.3. PRV
4.3.4. VZV
4.3.5. BHV-1
4.3.6. MDV
5. The Dynamic State of Alphaherpesvirus Latency
5.1. Data for Clinical Shedding
5.2. ``Spontaneous ́́Reactivation
5.3. Molecular Versus Clinical Reactivation
5.4. Transcriptional Activity During Latency
5.5. Evidence for TCell Regulation of Latency
6. Conclusions and Unanswered Questions
References
Chapter Three: Nuclear Egress of Herpesviruses: The Prototypic Vesicular Nucleocytoplasmic Transport 1. Introduction2. The Nucleus
2.1. The Nuclear Envelope
2.2. Lamins
2.3. Proteins of the INM
2.4. The LINC Between Cytoskeleton and Nucleus
2.5. Torsin
2.6. The Nuclear Pore Complex
2.7. Trafficking Across the NE
2.8. Dynamics of the NE
2.9. Cyclin-Dependent Kinases
2.10. Fusion Mechanisms Comprising the Nuclear Membranes
3. Herpesvirus Nuclear Egress
3.1. Nucleocapsid Formation
3.2. The Nuclear Egress Complex
3.3. Intranuclear Movement of Nucleocapsids to the INM
3.4. Alterations of the INM Environment to Facilitate Nucleocapsid Access
3.5. Nucleocapsid Docking at the NEC 3.6. Vesicle Formation and Scission3.7. The Primary Virion
3.8. Deenvelopment
4. Nuclear Egress as a Cellular Nuclear Export Mechanism
5. Alternative Herpesvirus Nuclear Escape Pathways
6. Nuclear Egress in Other Virus Families
7. Summary
Acknowledgments
References
Chapter Four: Structure and Associated Biological Functions of Viroids
1. Introduction
2. Biophysical Properties as Basis for Functional Activity
3. Structure of Pospiviroidae
3.1. Terminal Left (TL) Domain
3.2. Pathogenicity (P) Domain
3.3. Central (C) Domain
3.4. Variable (V) Domain
3.5. Terminal Right (TR) Domain