Advances in Translational Neuropathic Research: Example of Enantioselective Pharmacokinetic–Pharmacodynamic Modeling of Ketamine-induced Pain Relief in Complex Regional Pain Syndrome

Enantioselective pharmacokinetics of (R)

Enantioselective pharmacokinetics of (R)- and (S)-ketamine after a 5-day infusion in patients with complex regional pain syndrome

✍ Michael E. Goldberg; Marc C. Torjman; Robert J. Schwartzman; Donald E. Mager; Ir 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 133 KB 👁 1 views

## Abstract __Introduction__: This study determined the pharmacokinetics and pharmacodynamics of (__R__)‐ and (__S__)‐ketamine and (__R__)‐ and (__S__)‐norketamine following a 5‐day moderate dose, as a continuous (__R__,__S__)‐ketamine infusion in complex regional pain syndrome (CRPS) patients. __M