## Abstract We analysed the dynamic change of imatinib‐resistant mutations in BCR‐ABL kinase domain focusing on T315I mutation during dasatinib or nilotinib therapy. Fifty‐five imatinib‐resistant chronic myeloid leukaemia patients (32 patients with imatinib‐resistant mutations and 23 patients witho
✦ LIBER ✦
Advances in the structural biology, design and clinical development of Bcr-Abl kinase inhibitors for the treatment of chronic myeloid leukaemia
✍ Scribed by Paul William Manley; Sandra W. Cowan-Jacob; Jürgen Mestan
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 373 KB
- Volume
- 1754
- Category
- Article
- ISSN
- 1570-9639
No coin nor oath required. For personal study only.
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## Abstract Data demonstrating the superiority of nilotinib over imatinib in the frontline treatment of chronic myeloid leukemia (CML) and ongoing studies with dasatinib and bosutinib are rapidly changing the treatment landscape for CML. In this review, the authors discuss currently available thera