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Advances in preclinical cardiac xenotransplantation

✍ Scribed by C.G McGregor; S.S Teotia; J.M Schirmer; H.D Tazelaar; R.C Walker; R.P Frantz; G.W Byrne; J.M Risdahl; J.S Logan


Book ID
117710188
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
49 KB
Volume
22
Category
Article
ISSN
1557-3117

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The major barrier to clinically successful pig-to-human xenotransplantation is antibody-and complement-dependent hyperacute rejection, known to be due to host anti-GalΞ±(1,3)Gal antibodies. Strategies aimed at eliminating hyperacute rejection involve transgenic approaches to eliminate or reduce expre