## Abstract Nicotinic acetylcholine receptors (nAChRs), members of the Cysβloop ligandβgated ion channels (LGICs) superfamily, are involved in signal transduction upon binding of the neurotransmitter acetylcholine or exogenous ligands, such as nicotine. nAChRs are pentameric assemblies of homologou
β¦ LIBER β¦
Advances in our understanding of ligand-activated nuclear receptors
β Scribed by Dawn X Wen; Donald P McDonnell
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 952 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0958-1669
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β¦ Synopsis
During the past year, our understanding of signal transduction pathways mediated by nuclear receptors has advanced significantly. Progress was due, in part, to the identification of ligands for orphan receptors, to the discovery of proteins that interact with nuclear receptors and to genetic analyses in animal models using gene-knockout techniques.
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