Advances in MALDI and Laser-Induced Soft Ionization Mass Spectrometry

✍ Scribed by Rainer Cramer (eds.)

• Publisher: Springer International Publishing
• Year: 2016
• Tongue: English
• Leaves: 287
• Edition: 1
• Category: Library

✦ Synopsis

This book covers the state-of-the-art of modern MALDI (matrix-assisted laser desorption/ionization) and its applications. New applications and improvements in the MALDI field such as biotyping, clinical diagnosis, forensic imaging, and ESI-like ion production are covered in detail. Additional topics include MS imaging, biotyping/speciation and large-scale, high-speed MS sample profiling, new methods based on MALDI or MALDI-like sample preparations, and the advantages of ESI to MALDI MS analysis. This is an ideal book for graduate students and researchers in the field of bioanalytical sciences.

This book also:

• Showcases new techniques and applications in MALDI MS

• Demonstrates how MALDI is preferable to ESI (electrospray ionization)

• Illustrates the pros and cons associated with biomarker discovery studies in clinical proteomics and the various application areas, such as cancer proteomics

✦ Table of Contents

Front Matter....Pages i-xi
Front Matter....Pages 1-1
Employing ‘Second Generation’ Matrices....Pages 3-35
Efficient Production of Multiply Charged MALDI Ions....Pages 37-47
Front Matter....Pages 49-49
Ionic Liquids and Other Liquid Matrices for Sensitive MALDI MS Analysis....Pages 51-64
Coupling Liquid MALDI MS to Liquid Chromatography....Pages 65-76
Quantitative MALDI MS Using Ionic Liquid Matrices....Pages 77-90
Front Matter....Pages 91-91
Techniques for Fingermark Analysis Using MALDI MS: A Practical Overview....Pages 93-128
(MA)LDI MS Imaging at High Specificity and Sensitivity....Pages 129-147
Microprobe MS Imaging of Live Tissues, Cells, and Bacterial Colonies Using LAESI....Pages 149-167
MALDESI: Fundamentals, Direct Analysis, and MS Imaging....Pages 169-182
Front Matter....Pages 183-183
Disease Profiling by MALDI MS Analysis of Biofluids....Pages 185-196
MALDI Biotyping for Microorganism Identification in Clinical Microbiology....Pages 197-225
Future Applications of MALDI-TOF MS in Microbiology....Pages 227-246
Front Matter....Pages 247-247
Whole/Intact Cell MALDI MS Biotyping in Mammalian Cell Analysis....Pages 249-262
Food Authentication by MALDI MS: MALDI-TOF MS Analysis of Fish Species....Pages 263-277
Back Matter....Pages 279-286

✦ Subjects

Protein Science; Mass Spectrometry; Proteomics; Applied Microbiology; Biotechnology