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Advances in human cardiac 31P-MR spectroscopy: SLOOP and clinical applications

✍ Scribed by Markus von Kienlin; Meinrad Beer; Andreas Greiser; Dietbert Hahn; Kerstin Harre; Herbert Köstler; Wilfried Landschütz; Thomas Pabst; Jörn Sandstede; Stefan Neubauer

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
84 KB
Volume
13
Category
Article
ISSN
1053-1807

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✦ Synopsis

Abstract

Phosphorus magnetic resonance spectroscopy (^31^P‐MRS) has revealed a lot about the biochemistry of physiological and pathological processes in the heart. Nevertheless, until today, cardiac ^31^P‐MRS has not had any clinical impact, albeit some pioneering studies demonstrated that ^31^P‐MRS can indeed provide diagnostic information. In this paper, the development of techniques for human cardiac ^31^P‐MRS over the past decade is reviewed, and the requirements for a reliable clinical measurement protocol are discussed. Spatial localization with optimal pointspread function (SLOOP) is a new method to achieve spatial localization and absolute quantitation. Its properties are detailed, and preliminary findings in patients with dilated cardiomyopathy or myocardial infarction are presented. J. Magn. Reson. Imaging 2001;13:521–527. © 2001 Wiley‐Liss, Inc.

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