Advances in Diagnosis and Management of Cutaneous Adverse Drug Reactions: Current and Future Trends

✍ Scribed by Neil H. Shear, Roni P. Dodiuk-Gad

Publisher: Springer Singapore,Adis
Year: 2019
Tongue: English
Leaves: 307
Edition: 1st ed.
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

This resource guides prescribers, pharmacists, and regulators with an update on the recent expansion of basic and clinical knowledge that forms a framework for understanding cutaneous reactions. This understanding will lead, in turn, to better outcomes and decisions in treatment and management, both in the clinic and in the life cycle of drug development.
The skin is a common target for adverse drug events and even mild rashes can be part of life-threatening syndromes. Patients and practitioners often face important decisions about therapy after a drug eruption, including treatment, cross-reactivity with future pharmaceuticals, genetic considerations and dealing with long-term sequelae after a reaction. An international team of experts and leaders in the field share their story and insights into the scientific details and relevant clinical context.

✦ Table of Contents

Front Matter ....Pages i-xii
Front Matter ....Pages 1-1
Introduction: Classification, Terminology, Epidemiology, and Etiology of Cutaneous Adverse Drug Reactions (Maja Mockenhaupt)....Pages 3-20
Front Matter ....Pages 21-21
Immunology of Cutaneous Adverse Drug Reactions (Chuang-Wei Wang, Shuen-Iu Hung)....Pages 23-37
Pharmacogenomics and Cutaneous Adverse Drug Reactions (Ren-You Pan, Chun-Bing Chen, Wen-Hung Chung)....Pages 39-53
Viral Reactivation in Cutaneous Adverse Drug Reactions (Tetsuo Shiohara, Yoko Kano, Yoshiko Mizukawa, Yumi Aoyama)....Pages 55-65
Using Technology to Learn About Immunology of Cutaneous Adverse Drug Reactions (Ryan J. Schutte, David A. Ostrov)....Pages 67-74
Front Matter ....Pages 75-75
Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (Epithelial Necrolysis) (Jean-Claude Roujeau)....Pages 77-85
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) (Sylvia H. Kardaun)....Pages 87-104
Acute Generalized Exanthematous Pustulosis (Sima Halevy)....Pages 105-122
Urticarial Reactions to Drugs (Daniel F. Carr)....Pages 123-129
Dermatologic Adverse Events from Cancer Treatments (Jennifer Wu, Alina Markova, Mario E. Lacouture)....Pages 131-173
Cutaneous Adverse Drug Reactions in Pediatric Population (Ilan Fridental, Yaron Finkelstein)....Pages 175-184
Cutaneous Drug Reactions in the Elderly (James W. S. Young)....Pages 185-195
Cutaneous Adverse Drug Reactions in Human Immunodeficiency Virus Infection (Rannakoe J. Lehloenya, Jonny Peter)....Pages 197-205
Cutaneous Adverse Drug Reactions from Antituberculosis Treatment (Jonny Peter, Rannakoe J. Lehloenya)....Pages 207-215
Front Matter ....Pages 217-217
Practical Approach to Diagnosis and Management of Cutaneous Adverse Drug Reactions (Cristina Olteanu, Neil H. Shear, Roni P. Dodiuk-Gad)....Pages 219-226
Histopathology of Severe Drug Eruptions (Mari Orime, Riichiro Abe)....Pages 227-235
Evaluation of Drug Safety Literature: A Guide for the Practicing Dermatologist (Sandra R. Knowles, Jackie Campbell)....Pages 237-245
In Vitro and In Vivo Tests in Cutaneous Adverse Drug Reactions (Annick Barbaud)....Pages 247-263
Pharmacovigilance of Cutaneous Adverse Drug Reactions (Lois La Grenade, Maja Mockenhaupt, Elizabeth Phillips)....Pages 265-272
Front Matter ....Pages 273-273
Future Directions and Unmet Research Needs in Cutaneous Adverse Drug Reactions (Elizabeth Ergen, Jason Trubiano, Jonny Peter, Elizabeth Phillips)....Pages 275-282
Atlas of Cutaneous Adverse Drug Reactions (Alina G. Bridges, Kevin Brough)....Pages 283-314

✦ Subjects

Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology

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