Advances in Cancer Stem Cell Biology

✍ Scribed by Roberto Scatena (auth.), Roberto Scatena, Alvaro Mordente, Bruno Giardina (eds.)

Publisher: Springer-Verlag New York
Year: 2012
Tongue: English
Leaves: 348
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

In recent years, cancer stem cells have been recognized as important component in carcinogenesis and they seem to form the basis of many (if not all) tumor types. Cancer stem cells or "cancer cell like stem cells" have been isolated from various cancers of different origin (blood, breast, brain, skin, head and neck, thyroid, cervix, lung, retina, colon, pancreas and so on). Cancer stem cells - rare cells with indefinite proliferative potential that drive the formation and growth of tumours- seem to show intriguing relationships with physiological stem cells. Specifically, these cancer cells show significant similarities in the mechanisms that regulate self-renewal of normal stem cells. Moreover, tumour cells might directly arise from normal stem cells. Further, the cellular biology of cancer stem cells show a lot of similarities with normal stem cells.

✦ Table of Contents

Front Matter....Pages i-xii
Cancer Stem Cells: A Revisitation of the “Anaplasia” Concept....Pages 1-16
Stem Cells and Cancer Stem Cells: New Insights....Pages 17-31
Molecular Biology of Cancer Stem Cells....Pages 33-43
Biomarkers of Cancer Stem Cells....Pages 45-67
Cancer Stem Cells and the Microenvironment....Pages 69-84
Leukemia Stem Cells....Pages 85-103
Cancer Stem Cells and the Central Nervous System....Pages 105-121
Cancer Stem Cells and Glioblastoma Multiforme: Pathophysiological and Clinical Aspects....Pages 123-140
Breast Cancer Stem Cells....Pages 141-154
Colon Cancer Stem Cells....Pages 155-179
Liver Tumor-Initiating Cells/Cancer Stem Cells: Past Studies, Current Status, and Future Perspectives....Pages 181-196
Pancreatic Cancer Stem Cells....Pages 197-209
Cancer Stem Cells and Renal Carcinoma....Pages 211-220
Cancer Stem Cells: Proteomic Approaches for New Potential Diagnostic and Prognostic Biomarkers....Pages 221-238
Cancer Stem Cells: An Innovative Therapeutic Approach....Pages 239-266
Cancer Stem Cell and ATP-Binding Cassette: Which Role in Chemoresistance?....Pages 267-288
Stem Cells and Cancer Stem Cells: Biological and Clinical Interrelationships....Pages 289-300
Immunomodulatory Functions of Cancer Stem Cells....Pages 301-332
Back Matter....Pages 333-343

✦ Subjects

Cancer Research; Pharmacology/Toxicology

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