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Advances and applications of de novo designed affinity ligands in proteomics

✍ Scribed by A. Cecília A. Roque; Christopher R. Lowe

Book ID
113494532
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
393 KB
Volume
24
Category
Article
ISSN
0734-9750

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## Abstract Monoclonal anti‐HIV antibody 4E10 (mAb 4E10) is one of the most broadly neutralizing antibodies against HIV, directed against a specific epitope on envelope protein gp41. In the present study, a combinatorial __de novo__ design approach was used for the development of a biomimetic ligan