Advanced approach to build the design sp
β
Davide Fissore; Roberto Pisano; Antonello A. Barresi
π
Article
π
2011
π
John Wiley and Sons
π
English
β 542 KB
This paper deals with the design space of a pharmaceutical freeze-drying process. Mathematical modeling is used to investigate the effect of the operating conditions [shelf temperature (T shelf ) and chamber pressure (P c )] on product temperature (that has to remain below a limit value) and sublima