Adult T-cell Leukemia/Lymphoma

✍ Scribed by Toshiki Watanabe, Takuya Fukushima (eds.)

• Publisher: Springer Japan
• Year: 2017
• Tongue: English
• Leaves: 170
• Edition: 1
• Category: Library

✦ Synopsis

This book provides essential information on the epidemiology, molecular and genetic features, anti-CCR4 antibody therapy and a nationwide study of transplantation on human T-leukemia virus type-I (HTLV-1) and adult T-cell leukemia/lymphoma (ATL). This rare but important disease has restricted endemic areas and distinct clinical features such as a high frequency of hypercalcemia, strong predisposition to infection and poor response to chemotherapy, aspects which set ATL apart from other types of non-Hodgkin lymphoma. Given the small number of patients, enrollment in clinical trials has not been feasible, and establishing treatment standard has been difficult but new evidence, such as results of nationwide studies on transplantation, have shown new insights and potential treatments. Based on recent evidence, the book presents new treatment methods for ATL and infection prevention of HTLV-1, enabling clinicians, researchers and post-docs specializing in hematology and virology to gain a valuable overview of the disease.

✦ Table of Contents

Front Matter....Pages i-viii
Overview....Pages 1-2
Human T-Cell Leukemia Virus Type 1 (HTLV-1)....Pages 3-31
Epidemiology....Pages 33-48
Pathology....Pages 49-65
Immunophenotype....Pages 67-81
Leukemogenesis and Molecular Characteristics of Tumor Cells....Pages 83-100
Clinical Features of Adult T-cell Leukemia/Lymphoma (ATL)....Pages 101-107
Prognosis and Prognostic Index....Pages 109-116
Treatment of Indolent Adult T-cell Leukemia/Lymphoma (ATL)....Pages 117-124
Chemotherapy of Aggressive Adult T-cell Leukemia/Lymphoma (ATL)....Pages 125-131
Transplantation for Aggressive Adult T-Cell Leukemia/Lymphoma (ATL)....Pages 133-144
New Agents of Adult T-cell Leukemia/Lymphoma (ATL)....Pages 145-155
Prevention of Human T-Cell Leukemia Virus Type 1 (HTLV-1) Mother-to-Child Transmission....Pages 157-169

✦ Subjects

Hematology;Oncology;Infectious Diseases;Immunology