𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Adult stem cells in progression and therapy of hepatocellular carcinoma

✍ Scribed by Ingrid Herr; Ariane Groth; Peter Schemmer; Markus W. Büchler

Publisher
John Wiley and Sons
Year
2007
Tongue
French
Weight
278 KB
Volume
121
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Hepatocellular carcinoma is one of the most aggressive solid tumours associated with poor prognosis. Despite its significance, there is only an elemental understanding of the mechanisms that drive disease pathogenesis, and there are just limited therapy options. The medical community is currently experiencing a wave of enthusiasm for clinical trials, in which adult stem/progenitor cells are used for liver regeneration. This is based on promising results in animal models and encouraging reports from some initial clinical studies. On the other hand, several essential precautions are not being fully addressed. Stem cells may contribute to fibrosis or give rise to hepatic cancer stem cells as a source of hepatocellular carcinoma. This review outlines the current state of knowledge in progression of liver disease and highlights the function of adult stem cells in disease and therapy. © 2007 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Restriction of tumoricidal gene therapy
Restriction of tumoricidal gene therapy to selected hepatocellular carcinoma cells
✍ S Gagandeep; S Gupta 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 170 KB

gene therapy can be developed. These include: 1) improve- We have investigated whether adenovirally mediated ment of vector efficiency and 2) development of effective delivgene transfer of the thymidine kinase gene to human ery techniques, either of transduced cells or vectors directly hepatocellul