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Adult-onset still's disease.

✍ Scribed by K. B. Elkon; G. R. V. Hughes; E. G. L. Bywaters; P. F. J. Ryan; R. D. Inman; N. B. Bowley; M. P. James; R. A. J. Eady

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 848 KB
Volume: 25
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.1780250607

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✦ Synopsis

Eleven female patients with adult-onset Still's disease were followed for 7-36 years (mean 20.2 years) after the onset of their illness. Ten of these patients had a chronic course characterized by remissions and exacerbations of arthritis associated with fever and rash. Five patients had terminal interphalangeal involvement, and carpal ankylosis was demonstrated on x-ray film in 10. Two patients developed a widespread polyarthritis, and renal amyloidosis was diagnosed 10 years after disease onset in the most severely affected patient. In 4 patients studied during an exacerbation of the disease, circulating immune complexes were detected by the staphylococcal A binding assay, but not by the Clq binding assay. Synovial fluid analysis in 1 patient revealed a low C3 level and total hemolytic complement (CH50) together with immune complexes and IgG rheumatoid factor. Immune complexes were not identified in

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