Adult human retinal pigment epithelial cells capable of differentiating into neurons
β Scribed by Kaori Amemiya; Masatoshi Haruta; Masayo Takahashi; Mitsuko Kosaka; Goro Eguchi
- Book ID
- 116288026
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 282 KB
- Volume
- 316
- Category
- Article
- ISSN
- 0006-291X
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The human retinal pigment epithelium (RPE) is a potential target tissue for directed transfer of candidate genes to treat age-related macular degeneration (AMD). The RPE is uniquely suited to gene therapy protocols that use liposome-mediated DNA transfer because of its high intrinsic phagocytic func
Retinal pigment epithelial cells, which form one aspect of the blood-retinal barrier, take up iron in association with transferrin by a typical receptor-mediated mechanism (Hunt et al., 1989. J. Cell Sci. 92:655-666). This iron is dissociated from transferrin in a low pH environment and uptake is se