Adult cutaneous alveolar rhabdomyosarcoma on the face diagnosed by the expression of PAX3-FKHR gene fusion transcripts

Detection of the t(2;13)(q35;q14) and PA

Detection of the t(2;13)(q35;q14) and PAX3-FKHR fusion in alveolar rhabdomyosarcoma by fluorescence in situ hybridization

✍ Jaclyn A. Biegel; Lynn M. Nycum; Virginia Valentine; Frederic G. Barr; David N. 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 600 KB

Cytogenetic studies of the pediatric solid tumor alveolar rhabdomyosarcoma have demonstrated the presence of a consistent chromosomal translocation, t(2 I3)(q35;q 14). We recently identified PAX3 and FKHR as the genes on chromosomes 2 and I 3, respectively, that are juxtaposed by this translocation.