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Adsorption and association of 6-thiopurine and 6-thiopurine riboside at charged interfaces

✍ Scribed by Z.A Ahmed; M.E Ahmed; M.S Ibrahim; M.M Kamal; Y.M Temerk

Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 558 KB
Volume: 289
Category: Article
ISSN: 0003-2670
DOI: 10.1016/0003-2670(94)90009-y

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✦ Synopsis

A systematic study on the adsorption and association of 6-thiopurine (6-TP) and 6-thiopurine riboside (6-TPR) has been carried out at various pH values and the adsorption parameters were determined quantitatively. The adsorption was followed by out-of-phase alternating current voitammetry and cyclic voltammetry at a hanging mercury drop electrode. A comparative study was undertaken on the adsorption and association of the investigated thiopurines and the similar type of nucleic acid components containing purine bases. The base-containing thio group enhances stacking interaction and facilitates formation of the perpendicularly stacked layer on the electrode surface.

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