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Adrenomedullin and proadrenomedullin N-terminal 20 peptide in the normal prostate and in prostate carcinoma

✍ Scribed by Alfonso Calvo; Ibane Abasolo; Nuria Jiménez; Zhou Wang; Luis Montuenga

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
767 KB
Volume
57
Category
Article
ISSN
1059-910X

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✦ Synopsis

Abstract

There is increasing evidence for the important role played by regulatory peptides in the physiology of the normal and neoplastic prostate. Adrenomedullin (AM) and pro‐adrenomedullin N‐terminal 20 peptide (PAMP) are recently discovered regulatory peptides widely expressed in the normal prostate and in prostate carcinoma. AM is produced in secretory, stroma, and endothelial cells and in neurons of the prostate ganglia. PAMP is only produced by neuroendocrine cells. The expression of AM mRNA is regulated by androgens in the rat prostate. The number of neuroendocrine cells expressing PAMP is increased in prostate carcinoma after androgen deprivation, which shows that this peptide could regulate androgen‐independent prostate tumor growth. However, the roles of AM and PAMP in the normal prostate and in prostate carcinoma are yet to be elucidated. Microsc. Res. Tech. 57:98–104, 2002. © 2002 Wiley‐Liss, Inc.

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Peptidylglycine α-amidating monooxygenase- and proadrenomedullin-derived peptide–associated neuroendocrine differentiation are induced by androgen deprivation in the neoplastic prostate
✍ Nuria Jiménez; Johan Jongsma; Alfonso Calvo; Theodorus H. van der Kwast; Anthony 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 313 KB

Most PCs show NE differentiation. Several studies have tried to correlate NE expression with disease status, but the reported findings have been contradictory. Prostatic NE cells synthesize peptides with a wide spectrum of potential functions. Some of these active peptides, such as PAMP, are amidate