𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Adrenergic regulation of bone metabolism: Possible involvement of sympathetic innervation of osteoblastic and osteoclastic cells

✍ Scribed by Akifumi Togari

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
494 KB
Volume
58
Category
Article
ISSN
1059-910X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

It has been demonstrated that human osteoblastic as well as osteoclastic cells are equipped with adrenergic receptors and neuropeptide receptors and that they constitutively express diffusible axon guidance molecules that are known to function as a chemoattractant and/or chemorepellent for growing nerve fibers. These findings suggest that the extension of axons of sympathetic and peripheral sensory neurons to osteoblastic and osteoclastic cells is required for the dynamic neural regulation of local bone metabolism. Recently, bone resorption modulated by sympathetic stimulation was demonstrated to be associated with ODF (osteoclast differentiation factor) and OCIF (osteoclastogenesis inhibitory factor) produced by osteoblasts/stromal cells. This review summarizes the evidence implicating sympathetic neuron action in bone metabolism. The possible function of osteoclastogenesis, which could result in the initiation of sympathomimetic bone resorption, is also discussed. Microsc. Res. Tech. 58:77–84, 2002. © 2002 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Expression and regulation of resistin in
Expression and regulation of resistin in osteoblasts and osteoclasts indicate a role in bone metabolism
✍ Liv Thommesen; Astrid Kamilla Stunes; Marta Monjo; Kristin Grøsvik; Margareth V. 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 195 KB

## Abstract The adipose tissue is the site of expression and secretion of a range of biologically active proteins, called adipokines, for example, leptin, adiponectin, and resistin. Leptin has previously been shown to be expressed in osteoblasts and to promote bone mineralization, whereas adiponect

Regulation of bone resorption and osteoc
Regulation of bone resorption and osteoclast survival by nitric oxide: Possible involvement of NMDA-receptor
✍ R. Mentaverri; S. Kamel; A. Wattel; C. Prouillet; N. Sevenet; J. P. Petit; T. To 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 335 KB

## Abstract Nitric oxide has been shown to play an important role in regulation of bone resorption. However, the role of endogenous nitric oxide on osteoclast activity remains still controversial. In this work, using RT‐PCR amplification, we demonstrated that rabbit mature osteoclasts express mRNA