Adrenal-dependent leucopenia after short-term exposure to various airborne irritants in rats

✍ Scribed by M. T. Brondeau; P. Bonnet; J. P. Guenier; P. Simon; J. de Ceaurriz

• Book ID: 102289331
• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 314 KB
• Volume: 10
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/jat.2550100204

✦ Synopsis

Leucopenia without any change in differential or red blood cell counts was observed in rats exposed for 4 h to increasing concentrations of the following airborne irritants: acetic acid, benzyl chloride, 1,2-dichlorobenzene, ethyl acetate, ethyl acrylate, formaldehyde, isophorone, mesityl oxide, phenol, styrene, toluene diisocyanate and vinyl toluene. This effect was abolished by adrenalectomy. Vinyl toluene and 1,2-dichlorobenzene induced leucopenia at levels as low as their current occupational standards of 50 ppm. With the exception of 1,2dichlorobenzene, the tested compounds caused leucopenia only when exposure reached the irritant level. It is discussed that stress associated with the irritative effect of chemicals can confound specific haematological effects.