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Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers

✍ Scribed by Boni, A.; Muranski, P.; Cassard, L.; Wrzesinski, C.; Paulos, C. M.; Palmer, D. C.; Gattinoni, L.; Hinrichs, C. S.; Chan, C.-C.; Rosenberg, S. A.; Restifo, N. P.

Book ID: 121681385
Publisher: American Society of Hematology
Year: 2008
Tongue: English
Weight: 866 KB
Volume: 112
Category: Article
ISSN: 0006-4971
DOI: 10.1182/blood-2008-07-169797

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Autolymphocyte therapy (ALT) is adoptive cellular therapy of neoplastic disease using ex vivo activation of autologous (human) or syngeneic (murine) lymphocytes from tumor-bearing hosts (TBH) by low doses of anti-CD3 monoclonal antibody (MAb) and a mixture of previously prepared autologous cytokines