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Adoptive immunotherapy with bispecific antibodies: targeting through macrophages

✍ Scribed by Chokri, M.; Girard, A.; Borrelly, M.C.; Oleron, C.; Romet-Lemonne, J.L.; Bartholeyns, J.


Book ID
123082878
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
394 KB
Volume
143
Category
Article
ISSN
0923-2494

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To develop an efficient strategy for the targeting of antitumor effector cells, we prepared bispecific antibody (BsAb) containing anti-CD3 and an anti-c-erbB-2 proto-oncogene product. The prepared BsAb specifically reacts with both c-erb6-2positive tumor cells and CD3+ CTL. Human CD4' helper/killer