Administration to mouse of endotoxin from gram-negative bacteria leads to activation and apoptosis of T lymphocytes
✍ Scribed by Ana Castro; Veronique Bemer; Alberto Nóbrega; António Coutinho; Paolo Truffa-Bachi
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 186 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0014-2980
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✦ Synopsis
Lipopolysaccharide (LPS) from gramnegative bacteria is a well-known T cell-independent B lymphocyte mitogen and macrophage/monocyte activator. While the conventional view holds that LPS is ignored by T cells, we report here that administration of LPS to mice activates all B cells, but also engages most CD4 and CD8 T cells, as measured by the expression of the activation markers CD69 and CD25 and by size increase. T cells recruited in endotoxin-treated mice showed, following in vitro stimulation by concanavalin A, altered patterns of cytokine production. In vivo, massive T cell apoptosis was evidenced in the days following LPS exposure. The present observation may contribute novel insights into the mechanisms of endotoxin shock and of the immunological consequences of gram-negative infections.