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Administration of recombinant IL-2 augments the level of serum IgM in an IL-2 deficient patient

✍ Scribed by S. Doi; O. Saiki; T. Hara; T. Sugita; K. Ha-Kawa; T. Tanaka; H. Hara; S. Negoro; H. Yabuuchi; S. Kishimoto

Publisher: Springer
Year: 1989
Tongue: English
Weight: 481 KB
Volume: 148
Category: Article
ISSN: 0340-6997
DOI: 10.1007/bf00441517

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✦ Synopsis

A patient with ataxia telangiectasia was treated with recombinant interleukin-2 (rIL-2) and the resulting immunological effects evaluated. The patient lacked IL-2 production, and immnnoglobulin synthesis was also impaired. Treatment with IL-2 selectively increased serum IgM without any significant side effects. Therapy also restored B-cell function in vitro, IgM production as well as the proliferative response to Staphylococcus aureus strain Cowan I. These results suggest that IL-2 treatment may correct both T-cell and B-cell defects.

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