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Administration of recombinant human erythropoietin alpha before autologous stem cell transplantation reduces transfusion requirement in multiple myeloma patients

✍ Scribed by Massimo Martino; Esther Oliva; Giuseppe Console; Caterina Stelitano; Mohamed Fujo; Giuseppe Messina; Giuseppe Irrera; Giulia Pucci; Rosalba Mandaglio; Vincenzo Callea; Francesco Nobile; Pasquale Iacopino; Fortunato Morabito


Book ID
106173338
Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
159 KB
Volume
13
Category
Article
ISSN
0941-4355

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## Abstract Dickkopf‐1 (DKK‐1) protein, a soluble inhibitor of Wnt signalling, has been implicated in the pathogenesis of myeloma bone disease through the suppression of osteoblast differentiation. In this study, serum concentrations of DKK‐1 were measured in 50 myeloma patients (32 at diagnosis an