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Administration of a selective endothelin-a receptor antagonist (BSF 208075) improves hepatic warm ischemia/reperfusion injury in pigs

✍ Scribed by H Witzigmann; S Ludwig; E Escher; B Armann; G Gäbel; D Teupser; A Tannapfel; U.C Pietsch; J Hauss; D Uhlmann


Book ID
117232552
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
52 KB
Volume
34
Category
Article
ISSN
0041-1345

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Tezosentan, a novel endothelin receptor
✍ Douglas G. Farmer; Fady Kaldas; Dean Anselmo; Masamichi Katori; Xiu-Da Shen; Cha 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 454 KB

This study investigated the effects of dual endothelin (ET) receptor blockade in rat models of liver ischemia and reperfusion injury (IRI). Three models of IRI were used: (1) in vivo total hepatic warm ischemia with portal shunting for 60 minutes with control (saline) and treatment groups (15 mg/kg